Search results for "Concentration dependent"
showing 5 items of 5 documents
The inherent structural instability: concentration-dependent transformation of pyrogallarene to pyrogallarene lactones.
2011
Pyrogallarene shows concentration-dependent instability in dilute solutions resulting in elimination of two ketene molecules and formation of pyrogallarene lactones. This unexpected phenomenon, which is not observed with resorcinarenes, highlights the significance of the four hydroxyl groups at 2-position for the molecular characteristics of pyrogallarenes.
Cytotoxicities of Polysubstituted Chlorodicarbonyl(cyclopentadienyl) and (Indenyl)ruthenium Complexes
2013
Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1–S transiton as evidenced by flow cytometry.
Differentiation of DctA and DcuS function in the DctA/DcuS sensor complex ofEscherichia coli: function of DctA as an activity switch and of DcuS as t…
2014
Summary The C4-dicarboxylate responsiveness of the sensor kinase DcuS is only provided in concert with C4-dicarboxylate transporters DctA or DcuB. The individual roles of DctA and DcuS for the function of the DctA/DcuS sensor complex were analysed. (i) Variant DctA(S380D) in the C4-dicarboxylate site of DctA conferred C4-dicarboxylate sensitivity to DcuS in the DctA/DcuS complex, but was deficient for transport and for growth on C4-dicarboxylates. Consequently transport activity of DctA is not required for its function in the sensor complex. (ii) Effectors like fumarate induced expression of DctA/DcuS-dependent reporter genes (dcuB–lacZ) and served as substrates of DctA, whereas citrate ser…
Morphological abnormalities induced by Fenoxycarb on the ectoparasitic larval stage ofPhanerotoma (Phanerotoma) ocularisKohl (Hym., Braconidae)
1993
The Juvenile Hormone Analog Fenoxycarb at concentrations of 0.001 μg/ml, 0.005 μ/ml, 0.01 μg/ml, 0.05 μg/ml and 0.1 μg/ml had an adverse effect on the ectoparasitic larva of Phanerotoma (Phanerotoma) ocularis when topically applied. The total percentage of abnormalities obtained was higher (63.3 %-93.3 %) if the treatment was applied on the third substage than when it was applied on the fourth substage (53.3 %-76.7%). The activity rate was concentration dependent for both substages. Zusammenfassung Durch Fenoxycarb-Behandlung hervorgerufene Abnormitaten bei Larven des Ektoparasiten Phanerotoma (Phanerotoma) ocularis Kohl (Hym., Braconidae) Topikalbehandlung der Larven von Phanerotoma (Phane…
Toxic Effect of Vancomycin on Viability and Functionality of Different Cells Involved in Tissue Regeneration
2020
To prevent infections local delivery of antibiotics is a useful tool. Especially in bone fractures, vancomycin impregnated bone cements are often used allowing high concentrations of antibiotics at the infection side without high serum concentrations. However, besides potential pathogens, cells involved in tissue regeneration may also be affected by the drug. We investigated the effect of vancomycin on the viability and functionality on osteoblasts, endothelial cells, fibroblasts and skeletal muscle cells. Our results show that the viability of all cells analyzed was reduced by vancomycin and that the observed effects were time and concentration dependent. The most pronounced toxic effect w…